Hemodynamics,
Engineering, &
Applied
Research in
Thrombosis
Reverse engineering hemostasis and thrombosis through mechanics
The overarching goal of our lab is to identify how mechanical stress impacts upon cell and protein function in the cardiovascular system, while advancing tools to diagnose and treat disease.
Thrombosis and hemostasis:
We are investigating rheological mechanisms that contribute to bleeding and/or thrombosis. Here, we combine advanced imaging, microfluidics, molecular biology and biophysical measurements. We specifically focus on platelet and von Willebrand factor mechanobiology.
Diagnostic and therapeutic devices:
Using engineering fundamentals combined with molecular biology, we are developing diagnostic devices to identify hemostatic defects of blood samples. We are also focused on improving patient outcomes on mechanical circulatory support by reducing the risk for bleeding and thrombosis.
Congenital heart defects:
Using zebrafish as a model and investigating human fetal cardiovascular flow, our goal is to understand the role of mechanical forces in heart development and in the formation of cardiovascular malformations.